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METACRIN-DX - May Improve Phase I and
II Liver Detoxification
- Provides herbal support for normal Phase
I and II detoxification as well as healthy venous circulation
- Provides herbs that help encourage healthy
liver cell growth and RNA synthesis
- Provides the vitamins and amino acids required
for Phase I and II detoxification
Dosage: - 2-3 capsules 3x day.
Ingredients:Vitamin C
(as ascorbic acid) 25 mg 41%
Thiamin (as thiamin HCl) 5 mg 333%
Niacin (as niacinamide) 20 mg 100%
Pantothenic Acid (as calcium
pantothenate) 25 mg 250%
Magnesium (as mag. citrate) 15 mg 4%
Zinc (as zinc glycinate) 10 mg 65%
Copper (as copper
gluconate) 200 mcg 10%
Molybdenum
(molybdenum chelate) 150 mcg 197%
Milk Thistle extract (seed) 100 mg *
Dandelion (root) 75 mg *
Gotu Kola Nut 50 mg *
Panax Ginseng root 40 mg *
L-Glutathione 10 mg *
Glycine 75 mg *
N-Acetyl L-Cysteine 55 mg *
DL-Methionine 75 mg *
Bromelain 350,000 FCC *
Proprietary Blend: 54 mg of Trimethyl-glycine*, Betaine HCl*, Cellulase (plant enzyme)*, Peptidase (plant enzyme)*.
Dosage: Take 2 capsules 3x day.
RESEARCH:
DANDELION (TARAXACUM OFFICINALE) - Dandelion
root has physiologic impacts on both the liver and gallbladder. It impacts the liver by promoting the production
of bile and its delivery to the gallbladder. It impacts the gallbladder by causing contraction and release of stored
bile.11 12 13
MILK THISTLE (SILYBUM MARIANUM) has the ability
to increase the solubility of bile and its use has been shown to significantly reduce biliary cholesterol concentrations
and bile saturation index.14 It has potent antioxidant activity which supports phase I detoxification and prevents
the depletion of hepatic glutathione which is important for phase II detoxification.15 16 17 Silybum marianum has
anti-inflammatory chemical properties that are inhibitors of inflammatory prostaglandins and leukotriens as well
as chemical properties that promote protein synthesis to replace damaged liver cells. 18 19 20 21
CENTELLA ASITICA has active constituents
known as triterpenoid compounds that have impacts on cells and tissues that are important in detoxification. It
has even shown the ability to improve histological findings of liver cirrhosis.22 23 It also supports hepatic detoxification
due to its physiological impact on enhancing venous circulation. Centella Asitica has shown the ability to improve
venous disorders such as chronic venous insufficiency and venous hypertension.24 25 Improved venous circulation
has influential roles in optimizing detoxification that are generally overlooked.
11 Faber K. The dandelion Taraxacum officinale.
Pharmaize 1958;13:423-436.
12 Susnik F. Present state of knowledge of the medicinal plant Taraxacum officinale. Weber. Med Razgledi 1982;21:323-328.
13 Bohm K. Choleretic action of some medicinal plants. Arzneimittel Forsch 1959;9:376-378.
14 Nassauto G et al. Effects of silbinion on biliary lipid composition. Experimental and clinical study. J Hepatol
1991;12:290-295.
15 Wagnar H. Antihepatotoxic flavonioids. In: CodyV, Middleton E, Harbourne JB, eds. Plant flavonoids in biology
and medicine: biochemical, pharmacological, and structure-activity relationships. New York, NY: Alan R Liss. 1986:p545-558
16 Adzet T. Polyphenolic compounds with biological activity and pharmacological activity. Herbs Spices Medicinal
Plants 1986;1:167-184
17 Hikino H, Kiso Y, Wagner H. Antihepatotoxic actions of flavanolignans from Silybum marianum fruits. Plant Medica
1984;50:248-250.
18Fiebrich F, Koch H. Siymarin, an inhibitor of prostaglandin synthetase. Experentia 1979;35:150-152.
19 Feibrich F, Koch H. Silymarin an inbitor of lipoxygenase. Experentia 1979;35:148-150.
REFERENCE INFO
20 Palasciano G, Protinacasa P, et al. The effect of silymarin on plasma levels of malonadialdehyde in patients
receiving long-term treatment of psychotropic drugs. Curr Ther Res 1994;55:537-545.
21 Sonnenbicher J, Goldberg M, Hane L, et al. Stimulatory effect of silibinin on the DNA synthesis in partially
hepatectomized rat livers. Non-responsive in hepatoma and other malignant cel lines. Biochem Pharm 1986;35:538-541.
22 Darnis F, Orcel L, de Saint-Maur PP, Mamaou P. Use of a titrated extract of Centella asiatica in chronic hepatic
disorders. Sem Hosp Paris 1979;55:1749-1750.
23 El Zawahry MD, Kahil AM, El Banna MH. Madecassol. A new therapy for hepatic fibrosis. Bull Soc Int Chir (Belgium)
1975;34:296-297.
24 Belcaro GV, Grimaldi R, Guidi G. Improvement of capillary permeability in patients with venous hypertension
after treatment with TTFCA. Angiology 1990; 41(7):533-540.
25 Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatca (TECA) in the treatment of venous
insufficiency of the lower limbs. Angiology 1987;38(11):46-50.
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